Psoriatic arthritis causes

A combination of factors is believed to influence whether someone is at risk for psoriatic arthritis, including your family history and genetics, environmental factors, and how your immune system functions.

  • The inflammation associated with psoriatic arthritis is caused by an abnormal response of your immune system, which is your body’s system of defense against bacteria, viruses, and other harmful substances. In psoriatic arthritis, the immune system overreacts and mistakenly attacks healthy cells and tissues in the joints as well as in the skin.
  • Psoriatic arthritis tends to run in families. Researchers have found that certain genes are linked to an increased risk of developing the disease.
  • Substances in the environment, or an event such as a trauma, infection (such as a streptococcal throat infection), or contracting a virus are thought to possibly trigger psoriasis and/or psoriatic arthritis in people who have a genetic predisposition.

Could you have too much inflammation?

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Have you been diagnosed with PsA, Ps, or neither? Select one.

Since you selected PsA, you might want to learn more about PsA inflammation and disease progression.

Since you selected Ps, you might want to know that 1 in 3 people diagnosed with Ps may develop PsA. Could you have PsA?

Since you selected "neither," find out if your skin and joint symptoms could be psoriatic arthritis.

Who gets psoriatic arthritis?

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About 1 in 3 people with psoriasis may develop PsA.

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It can take up to 10 years for joint symptoms to appear after skin symptoms appear.

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PsA is equally common in men and women.

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Most people develop psoriatic arthritis between 30 and 50 years of age, although it can develop at any age.

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People without psoriasis can also develop psoriatic arthritis, particularly if they have a family member with psoriasis or psoriatic arthritis.

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Understand PsA Inflammation

Chronic inflammation can cause irreversible joint damage—and may affect other parts of your body.

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Find a Psoriatic Arthritis Doctor

Find a rheumatologist, an expert on both the diagnosis and management of psoriatic arthritis.

Sources: 1. Gottlieb A, Korman NJ, Gordon KB, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: section 2. Psoriatic arthritis: overview and guidelines of care for treatment with an emphasis on the biologics. J Am Acad Dermatol. 2008;58(5)851-864. doi: 10.1016/j.jaad.2008.02.040. 2. Gottlieb A, Merola JF. Psoriatic arthritis for dermatologists. J Dermatolog Treat. 2019;1-18. doi: 10.1080/09546634.2019.1605142. 3. Immune response. MedlinePlus. Updated February 2, 2020. Accessed August 10, 2020. https://www.nlm.nih.gov/medlineplus/ency/article/000821.htm. 4. Psoriatic arthritis. American College of Rheumatology. Updated March 2019. Accessed August 10, 2020. https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Psoriatic-Arthritis. 5. Psoriatic arthritis. Arthritis Foundation. Accessed August 10, 2020. https://www.arthritis.org/diseases/psoriatic-arthritis.

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